Scoring ▪ Game
| Player | Class | Pos | Points | Opponent | |
|---|---|---|---|---|---|
| 1. | Quentin Griffin | SO | RB | 36 | 2000 vs Texas |
| 2. | Joe Mixon | SO | RB | 30 | 2016 at Texas Tech |
| 3. | Samaje Perine | FR | RB | 30 | 2014 Kansas |
| 4. | DeMarco Murray | FR | RB | 30 | 2007 North Texas |
| 5. | Kejuan Jones | SO | RB | 30 | 2003 at Texas Tech |
| 6. | Jerald Moore | JR | TB | 30 | 1994 at Oklahoma State |
| 7. | Steve Owens | JR | TB | 30 | 1968 Nebraska |
| 8. | Rodney Anderson | SO | RB | 24 | 2017 West Virginia |
| 9. | Rodney Anderson | SO | RB | 24 | 2017 TCU |
| 10. | Samaje Perine | SO | RB | 24 | 2015 Texas Tech |
| 11. | Samaje Perine | FR | RB | 24 | 2014 at West Virginia |
| 12. | Kenny Stills | JR | WR | 24 | 2012 at West Virginia |
| 13. | Blake Bell | SO | QB | 24 | 2012 vs Texas |
| 14. | Damien Williams | JR | RB | 24 | 2012 Florida A&M |
| 15. | Blake Bell | FR | QB | 24 | 2011 at Baylor |
| 16. | Dominique Whaley | JR | RB | 24 | 2011 Tulsa |
| 17. | Jermaine Gresham | SO | TE | 24 | 2007 Texas A&M |
| 18. | Quentin Griffin | SR | RB | 24 | 2002 at Baylor |
| 19. | Quentin Griffin | JR | RB | 24 | 2001 Tulsa |
| 20. | Trent Smith | JR | TE | 24 | 2001 at Kansas |
| 21. | Mike Gaddis | SR | TB | 24 | 1991 at Missouri |
| 22. | Jamelle Holieway | JR | QB | 24 | 1987 North Carolina |
| 23. | Earl Johnson | SR | HB/FB | 24 | 1986 at Kansas |
| 24. | J.C. Watts | SR | QB | 24 | 1980 Oklahoma State |
| 25. | Buster Rhymes | FR | RB | 24 | 1980 at Colorado |
| 26. | Billy Sims | SR | HB | 24 | 1979 at Oklahoma State |
| 27. | Billy Sims | SR | HB | 24 | 1979 Iowa State |
| 28. | Billy Sims | SR | HB | 24 | 1979 Colorado |
| 29. | Billy Sims | JR | HB | 24 | 1978 Oklahoma State |
| 30. | Billy Sims | JR | HB | 24 | 1978 Missouri |
| 31. | Joe Washington | JR | LHB | 24 | 1974 at Colorado |
| 32. | Roy Bell | SR | HB | 24 | 1971 at Kansas State |
| 33. | Steve Owens | SR | TB | 24 | 1969 Iowa State |
| 34. | Steve Owens | SR | TB | 24 | 1969 Colorado |
| 35. | Steve Owens | SR | TB | 24 | 1969 at Wisconsin |
| 36. | Steve Owens | JR | TB | 24 | 1968 Iowa State |
| 37. | Jim Grisham | JR | FB | 24 | 1963 Oklahoma State |
| 38. | Buddy Leake | FR | 24 | 1951 Oklahoma State | |
| 39. | George Thomas | SR | RB | 24 | 1949 Kansas |
NOTES
- Ties go to the most recent occurrence.