Strikeouts ▪ Season
| Player | Class | Season | SO | IP | SO/7 | BB | SO/BB | |
|---|---|---|---|---|---|---|---|---|
| 1. | Keilani Ricketts | 2012 | 457 | 292.0 | 10.96 | 51 | 8.96 | |
| 2. | Keilani Ricketts | 2011 | 452 | 284.1 | 11.13 | 82 | 5.51 | |
| 3. | Jill Most | 1996 | 356 | 295.2 | 8.43 | 113 | 3.15 | |
| 4. | Keilani Ricketts | SR | 2013 | 350 | 238.1 | 10.28 | 63 | 5.56 |
| 5. | Keilani Ricketts | 2010 | 346 | 259.2 | 9.33 | 91 | 3.80 | |
| 6. | Jill Most | 1997 | 307 | 253.1 | 8.48 | 54 | 5.69 | |
| 7. | Kelsey Stevens | SO | 2014 | 285 | 275.0 | 7.25 | 99 | 2.88 |
| 8. | Giselle Juarez | JR | 2019 | 269 | 186.1 | 10.11 | 38 | 7.08 |
| Paige Parker | SO | 2016 | 269 | 252.1 | 7.46 | 68 | 3.96 | |
| 10. | Kami Keiter | 2003 | 264 | 294.1 | 6.28 | 90 | 2.93 | |
| 11. | D.J. Mathis | JR | 2008 | 263 | 237.1 | 7.76 | 83 | 3.17 |
| 12. | Paige Parker | JR | 2017 | 262 | 210.1 | 8.72 | 47 | 5.57 |
| 13. | Lauren Eckermann | 2007 | 259 | 274.1 | 6.61 | 50 | 5.18 | |
| 14. | Brea Moore | 1995 | 226 | 219.1 | 7.21 | 66 | 3.42 | |
| 15. | Paige Parker | FR | 2015 | 224 | 217.0 | 7.23 | 57 | 3.93 |
| 16. | Kami Keiter | 2005 | 221 | 239.1 | 6.46 | |||
| 17. | Paige Parker | SR | 2018 | 213 | 187.2 | 7.94 | 38 | 5.61 |
| 18. | Michelle Gascoigne | SR | 2013 | 210 | 136.0 | 10.81 | 29 | 7.24 |
| 19. | Jordyn Bahl | FR | 2022 | 205 | 141.1 | 10.15 | 34 | 6.03 |