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Strikeouts ▪ Career
| Player | Seasons | SO | IP | SO/7 | BB | SO/BB | |
|---|---|---|---|---|---|---|---|
| 1. | Keilani Ricketts | 2010-13 | 1605 | 1074.1 | 10.46 | ||
| 2. | Paige Parker | 2015-18 | 968 | 867.1 | 7.81 | 210 | 4.61 |
| 3. | Jill Most | 1994-97 | 805 | 671.2 | 8.39 | ||
| 4. | Kami Keiter | 2002-05 | 733 | 910.1 | 5.64 | ||
| 5. | Jennifer Stewart | 1999-02 | 634 | 928.2 | 4.78 | ||
| 6. | D.J. Mathis | 2006-09 | 597 | 637.0 | 6.56 | ||
| 7. | Michelle Gascoigne | 2010-13 | 528 | ||||
| 8. | Patti Graham | 1981-84 | 462 | 807.1 | 4.01 | ||
| Cheryl Jacobs | 1978-80 | 462 | 752.1 | 4.30 | |||
| 10. | Kelsey Stevens | 2014-16 | 456 | 429.0 | 7.44 | 203 | 2.25 |
| 11. | Giselle Juarez | 2019-21 | 437 | 321.0 | 9.53 | 66 | 6.62 |
| 12. | Nicole May | 2021-24 | 421 | 371.1 | 7.94 | 107 | 3.93 |
| 13. | Lana Moran | 1997-00 | 420 | 621.1 | 4.73 | ||
| 14. | Jordyn Bahl | 2022-23 | 397 | 289.2 | 9.59 | 71 | 5.59 |
| 15. | Mariah Lopez | 2017-19 | 355 | 295.0 | 8.42 | 55 | 6.45 |
| 16. | Shannon Saile | 2019-21 | 347 | 249.0 | 9.76 | 97 | 3.58 |
| Lauren Eckermann | 2007-08 | 347 | 387.2 | 6.27 | 72 | 0.00 | |
| 18. | Nicole Denes | 2003-06 | 325 | ||||
| 19. | Brea Moore | 1994-95 | 311 | ||||